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Published on June 26, 2024
Researchers from Baylor College Medicine mined data from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and other publicly available data sites to identify possible new therapeutic targets represented across 10 different cancer types. Their study, published in Cell, delves into the intricacies of proteomics, genomics, and epigenomics data to identify…
Published on June 25, 2024
Two separate Phase III clinical trials have shown that the diabetes and obesity drug tirzepatide led to significant decreases in the in the number of breathing interruptions during sleep of patients with obstructive sleep apnea (OSA), setting it up as potentially the first medication to treat the disorder. The results…
Published on June 24, 2024
An analysis of the genetic profiles of thousands of neurons from postmortem brain tissue of people with amyotrophic lateral sclerosis (ALS) and from healthy donors has revealed how a set of genes could cause neuron loss in ALS and frontal temporal dementia (FTD). The study, which was funded by the…
Published on June 21, 2024
A vaccine for Parkinson’s disease could be on the horizon, according to a new study published in Nature Medicine. Vaxxinity’s immunotherapy targeting pathogenic α-synuclein aggregates has achieved its immunogenicity, safety, and tolerability goals in a phase I clinical trial in Parkinson’s patients. The vaccine, known as UB-312, was shown to…
Published on June 20, 2024
People resistant to COVID-19 have “never-seen-before” immune responses and possibly high levels of HLA-DQA2. These findings come from researchers at the Wellcome Sanger Institute, University College London (UCL), Imperial College London, the Netherlands Cancer Institute, and their collaborators who used data from a unique “challenge study.” Severe acute respiratory syndrome…
Published on June 17, 2024
A cross-omics approach identified four distinct molecular profiles of Alzheimer’s Disease, one of these profiles was associated with worse cognitive function and neuropathological features, according to researchers at Beth Israel Deaconess Medical Center (BIDMC) and their collaborators. The symptoms in this poorer prognosis group included significantly higher Clinical Dementia Rating…
Published on June 5, 2024
Researchers at the University of Copenhagen have shown that using a commercially available AI system can reduce the workload of radiologists by over 33% while improving the overall performance of breast cancer screenings. Mammography exams are routinely used for the early detection of breast cancer, which helps reduce the mortality…
Published on May 22, 2024
A retrospective study of screening mammograms assessed by an FDA-approved AI algorithm revealed higher rates of false positive case scores in African-American women and older women compared to White and younger patients. The same algorithm also revealed that false positive case scores were less likely in Asian patients compared with…
Published on May 15, 2024
Researchers from the Vanderbilt-Ingram Cancer Center identified new genome-wide gene variants at 12 different locations associated with breast cancer in women of African ancestry. They discovered that variants in three of the 12 were associated with triple-negative breast cancer (TNBC). Historically, women of African ancestry have been largely underrepresented in…
Published on May 7, 2024
Broken String Biosciences and the Francis Crick Institute are partnering to develop novel applications for the start-up’s proprietary DNA break-mapping platform, INDUCE-seq, to investigate the impact of genomic instability in the development of amyotrophic lateral sclerosis (ALS). The partnership will examine DNA break-mapping technology and advance understanding of genomic instability…
Published on April 17, 2024
A retrospective study led by researchers at Washington University School of Medicine in St. Louis and Whiterabbit.ai showed that an artificial intelligence (AI)-based protocol theoretically reduced the number of false positive results from routine mammograms. The study is published in Radiology: Artificial Intelligence. Acknowledging that many AI-based studies in breast…
Published on April 3, 2024
By analyzing the nearly 6,000 Major Histocompatibility Complex-1(MHC-1) proteins in the human body, researchers from Arizona State University (ASU) were able to classify them into 11 different types according to their electrostatic signatures. Their new human leukocyte antigen (HLA)-Inception tool, created by AI and machine learning, revealed that individuals with…
Published on March 27, 2024
Researchers have developed a new atlas of rare hematopoietic stem and progenitor cells, those cells that trigger production of mature blood cells. Their studies showed that the atlas can aid in predicting which acute myeloid leukemia (AML) patients will respond to current standard therapy with venetoclax and azacytidine. The scientists…
Published on March 22, 2024
In a recent breakthrough at the University of Michigan, researchers have shed light on the interplay between diet, genetics, and the gut microbiome, offering fresh insights into the triggers of inflammatory bowel disease (IBD). IBD, characterized by symptoms such as abdominal pain, diarrhea, and weight loss, has long puzzled the…
Published on March 13, 2024
The National Institutes of Health (NIH) announced Tuesday the launch of two Phase II clinical trials to evaluate the safety and effectiveness of three treatments for adults suffering from long COVID with autonomic nervous system dysfunction. The trials are a part of the NIH’s Researching COVID to Enhance Recovery (RECOVER)…