Researchers at the University of California (UC) Irvine have conducted a transcriptomics analysis of Alzheimer’s disease, looking at the spatial differences in gene expression found across the brains of patients with early-stage and late-stage Alzheimer’s, as well as Alzheimer’s disease in Down syndrome. Their results, published in Nature Genetics, uncovered…

A study conducted by researchers at the Johns Hopkins University School of Medicine and Tufts University School of Medicine, shows that a synthetic THC, known as dronabinol, has been shown to effectively reduce agitation in Alzheimer’s disease (AD) patients. The findings, presented at the International Psychogeriatric Association conference in Buenos…

An international team of researchers has developed a promising new drug that works on both major Tau protein aggregation “hotspots,” a key driver of neurodegeneration including Alzheimer’s disease. The novel peptide inhibitor, RI-AG03, has demonstrated efficacy in preventing Tau aggregation in both laboratory and fruit fly studies, while showing no…

Researchers from the Medical Research Council Laboratory of Molecular Biology (MRC LMB) in Cambridge, England and the UK Dementia Research Institute (UK DRI) at the University of Cambridge have developed new potential therapies that selectively remove the aggregated tau tangles to treat Alzheimer’s disease (AD). Their work, detailed in two…

A novel technique developed by researchers at the Washington University (WashU) School of Medicine has allowed them to study aged neurons in the lab without the need for a brain biopsy. The technique has identified aspects of the genome of cells in the development of late-onset Alzheimer’s disease (AD) that…

A research team led by the Broad Institute of MIT and Harvard has mapped gene expression across six areas of the brain linked to Alzheimer’s disease using a single-cell transcriptomics approach. Writing in Nature, the authors explain that they were able to map 1.3 million cells from 283 post-mortem brain…

Dementia is an early sign of Alzheimer’s disease, but not all patients with it will go on to develop the progressive brain disorder for which there is no cure. Early detection, however, allows for the treatment of symptoms and the building support and medical care teams. Now, a team of…

The Davos Alzheimer’s Collaborative (DAC) announced that it will collaborate with health systems in Germany, the U.K., Japan, the U.S., and the Netherlands to leverage blood biomarkers and confirmatory diagnostic testing to for early identification of Alzheimer’s disease and related dementias (ADRD). The goal of the Accurate Diagnosis project is…

A multinational research collaboration led by researchers at the University of Kentucky Sanders-Brown Center on Aging have used long-read RNA sequencing to identify 53 new RNA isoforms in medically relevant genes related to Alzheimer’s disease (AD) and other neurodegenerative diseases. Their study, published in Nature Biotechnology, is part of an…

Icahn School of Medicine at Mount Sinai researchers report that they have identified a novel method to potentially slow or even halt progression of Alzheimer’s disease (AD) by manipulating cellular interactions of protein around myeloid plaques. The new findings, published in the journal Nature Neuroscience, focuses on the role of…

Research led by Columbia University in New York has uncovered a genetic variant in the gene encoding fibronectin 1 (FN1) that protects against Alzheimer’s disease in carriers of the high risk APOE4 allele. It appears to do this by preventing excessive build-up of fibronectin in the blood brain barrier, something…

Research led by Washington University in St. Louis carried out in animals shows that restoring the activity of microglial cells in the brain could be a new treatment strategy for Alzheimer’s disease. Approximately 5.8 million people in the United States have Alzheimer’s disease or related dementias. Treatments for the condition…

New research published today by investigators from the Boston University School of Public Health (BUSPH) and the UTHealth Houston School of Public Health has identified 17 significant genetic variants in five genomic regions that are associated with Alzheimer’s disease (AD). The study, published in the journal Alzheimer’s & Dementia: The…

Researchers from the University of Illinois Urbana-Champaign studying mouse models of Alzheimer’s disease (AD) have found the earliest biomarker of the disease to date. The biomarker, a neural-specific protein in the brain, exhibits increased activity that leads to seizures associated with the earliest stages of neurodegeneration. Reporting Wednesday in EMBO…

Virtual reality headsets can reveal navigational issues in people at increased risk of Alzheimer’s disease before any declines in memory appear, research shows. The headsets flagged spatial navigation problems even when there were no concerns in cognitive tests, according to the findings in Alzheimer’s & Dementia: The Journal of the…