Collaborators from the Children’s Hospital Los Angeles (CHLA) and the radiation oncology software company Voxel Healthcare have been awarded a $2.1 million grant to advance the company’s AI-driven clinical decision support product for pediatric brain radiation therapy planning. The product, ClickBrain RT, uses deep learning technologies to automatically identify and…

New evidence suggests lymph nodes play a key role in why tumors that have spread to the brain respond to immunotherapy, while glioblastoma, which originates in the brain, does not. “Typically, antigen presenting cells (e.g., conventional dendritic cells, cDCs) are recruited to the tumor, where they phagocytose dead or dying tumor…

A new tool developed by researchers at Harvard Medical School (HMS) uses artificial intelligence (AI) to determine the molecular profile of a patient’s brain tumor during surgery. The advance can help surgeons know how much tissue to remove during surgery or whether to place tumor-killing drugs directly in the brain…

A multicenter research and development effort led by a team of neurosurgeons and engineers at Michigan Medicine at the University of Michigan (U-M) have developed a screening system call DeepGlioma that employs rapid imaging plus artificial intelligence (AI) to detect brain cancer mutations in under 90 seconds. “This AI-based tool…

A novel technology designed to precisely image aggressive brain cancers and guide treatment is being prepared for a phase 1 trial in glioblastoma, the most common type of brain cancer. The new MRI nanotechnology targets a specific marker, fibroblast activation protein (FAP), that is found in the majority of solid…

When Anne Donguy’s son, Anatole, was diagnosed with diffuse midline glioma in May 2018, she joined the ranks of many parents around the world looking for any effective treatment for their child. Living in Stockholm, Sweden, Anne and her family eventually learned that the most hopeful drug treatment, Onc201, was…

Brain metastases are the most common tumor of the brain with a very poor prognosis. A fraction of patients with brain metastasis benefit from treatment with immune checkpoint inhibitors like anti-PD1, anti-PD-L1, and anti-CTLA4 drugs. One of the limitations of these drugs over the long-term in brain tumors is that…

Scientists at Dana-Farber Cancer Institute, Massachusetts General Hospital, and the Broad Institute of MIT and Harvard, reported the discovery of a potential new target for immunotherapy of malignant brain tumors. The team used single-cell RNA sequencing (RNA-seq) to study gene expression and the clonal landscape of tumor-infiltrating T cells across…

If you dispatch a suicide gene, you want to make sure that it bypasses healthy cells on its way to harmful cells, such as cancer cells. What’s more, you want to make sure that the suicide gene is sent via a delivery system that treads lightly—especially if the suicide gene…

Detecting, as well as treating, brain cancers has historically presented a challenge for researchers and clinicians. Though, with new techniques such as liquid biopsy and advanced sequencing methods, identifying tumors within the brain could become considerably easier. Now, investigators at the Cancer Research UK (CRUK) Cambridge Institute have made considerable…

A cache of brain cancer biomedical data, REMBRANDT (REpository for Molecular BRAin Neoplasia DaTa) hosted and supported by Georgetown, has been made available free to researchers worldwide. It is one of only two such large collections in the United States. Unlike many other such datasets, REMBRANDT contains not just genomic…

Philadelphia Coalition for a Cure (PC4C) said today it will partner with Children's Hospital of Orange County (CHOC) on a study of brain tumors in adults and children that will use NantHealth’s GPS Cancer molecular profiling and diagnostics test. GPS Cancer integrates whole genome (DNA) sequencing of over 20,000 genes…

Scientists at the Translational Genomics Research Institute (TGen) have just published evidence suggesting that survival from glioblastoma (GBM), an aggressive and deadly form of brain cancer, could be determined by the complexity of their tumor. The findings from this new study, which were published recently in Neuro-Oncology through an article…

Researchers at the Dana-Farber Cancer Institute, reporting at the European Society of Medical Oncology Congress in Barcelona, say that an antibody-drug conjugate that delivers chemotherapy directly to the tumor site has shown “impressive” activity against HER2-positive breast cancer that has spread to the brain. The findings, according to the study…

Drexel University College of Medicine investigators have discovered two drug-like molecules that show early promise to shrink brain tumors caused by metastatic breast cancer. Their research in a mouse model, published in the journal Frontiers in Pharmacology, represents the first successful attempt to target a key metabolic enzyme in brain…