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Published on March 13, 2024
Pearl Bio yesterday announced that it has entered a collaboration with Merck, known as MSD outside of the United States and Canada, to discover biologic therapies comprising non-standard amino acids for drug discovery. Such synthetic biology efforts are increasing, as it’s believed that expanding the genetic code could provide new…
Published on December 15, 2023
Machine learning and structural biology company Atomic AI announced that it has created the first large language learning model that leverages chemical mapping data to optimize RNA therapeutic development by predicting the structure and function of RNA. The company details the development of its proprietary technology, called ATOM-1, in a…
Published on October 11, 2023
Researchers have identified more than 1,000 functional new druggable cancer drug targets using a combination protocol involving gene base editing and chemical proteomics. The research, published in Nature Chemical Biology, focused on editing thousands of bases on more than 1,750 genes known to be correlated with cancer development. The work…
Published on August 16, 2022
Before COVID engulfed the world in crisis, another microbial threat loomed large: antimicrobial resistance. In the U.S. alone, more than 2.8 million people acquire antibiotic-resistant infections each year and 35,000 die as a result. Scientists have been warning about an impending crisis for decades as the pipeline for new antibiotics…
Published on May 14, 2019
VIEW NOW Broadcast Date: June 26, 2019Time: 8:00 am PT, 11:00 am ET, 17:00 CET Protein structure must be studied in its native cellular environment, otherwise, we risk overlooking the molecular crowding effects that new mass spectrometry (MS) based structural methods reveal about protein architecture in intact cells and cell…
Published on July 27, 2023
The University of Texas MD Anderson Cancer Center and start up Nexo Therapeutics have announced a multi-year strategic collaboration for new cancer therapies against previously undruggable targets. The agreement links Nexo’s drug discovery platform, which combines innovative covalent chemistry and chemical biology, with MD Anderson’s expertise in translational research and drug development.…
Published on April 1, 2024
Biologists of all sorts seek the answer to this general question: What happens and where? The complexity of the answer and even the ability to address the question depends intimately on the problem being studied. A chain of technological advances over centuries, however, continues to give biologists tools to explore…
Published on March 6, 2024
Scientists at the University of California, San Francisco, have found a way to target K-Ras-G12D mutations, which are especially prevalent in pancreatic ductal adenocarcinoma. This marks an important breakthrough as K-Ras mutations are were considered until recently, to be all but undruggable. But ever since the arrival of sotorasib and…
Published on December 28, 2023
A new class of drugs have been synthesized, which could address a long-standing pharma challenge—cyclic peptides that can be given orally. A team from École Polytechnique Fédérale de Lausanne (EPFL) has generated such cyclic peptides that can target thrombin. The study was published in Nature Chemical Biology, by scientists from the…
Published on September 14, 2023
Researchers at the University of Maryland School of Medicine (UMSOM) and their Wake Forest University (WFU) colleagues have discovered that a compound known as ferroheme can bind and distribute nitric oxide (NO) throughout the vascular system, enabling regulation of blood flow, blood pressure and other signaling processes involved in healing…
Published on August 2, 2023
Researchers at City of Hope have developed a new targeted chemotherapy that shows promise against all solid tumor types, in preclinical studies. The new drug candidate, AOH1996, targets proliferating cell nuclear antigen (PCNA) a protein once that to be “undruggable” with early research showing that the targeted chemotherapy appears to…
Published on July 13, 2023
By combining artificial intelligence with an infrared biosensor, researchers have been able to distinguish between different types of misfolded proteins implicated in a variety of neurodegenerative diseases. Recent studies suggest that differences in the structure of harmful sticky protein clumps in the brains of patients with Parkinson’s disease could explain…
Published on May 25, 2023
North-American researchers have used machine learning to discover a new compound that controls bacterial infection, highlighting the value of artificial intelligence in antibiotic discovery. Screening around 7500 molecules revealed that the antibacterial compound abaucin, which was originally touted as an anti-diabetes drug, could inhibit the growth of Acinetobacter baumannii in vitro.…
Published on March 2, 2023
A novel system developed by researchers at the University of Pittsburgh and the University of Kent provides an unparalleled level of detail that helps explore how cells find and repair damaged DNA. The findings published in the journal of Nucleic Acids Research may lead to novel strategies and therapies for…
Published on February 10, 2023
William Haseltine It is becoming increasingly clear that we have misunderstood SARS-CoV-2, the virus that causes COVID-19. Many people, including some experts in the scientific community, deemed the pandemic over with the release of the mRNA vaccines. The belief—or perhaps it was hope in disguise—was that…