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Published on September 17, 2024
Certain rare variants have around five times larger effects on menopause timing than do previously identified common variants. Those rare variants included ETAA1, ZNF518A, PNPLA8, PALB2, and SAMHD1. A British research team mined UK BioBank data for this study, which appeared in Nature. Further, they found that damaging germline variants…
Published on September 16, 2024
A new large-scale, meta-analysis, suggests hormone replacement therapy (HRT) can control insulin resistance in healthy, post-menopausal women. This finding could help guide the use of HRT, something that has long been controversial but could apparently have substantial benefits for certain patients. Results of the meta-analysis, which included over 17 trials,…
Published on August 27, 2024
Research led by the University of Iceland and deCODE genetics has discovered a genetic variant that appears to significantly increase a woman’s risk of early menopause. The single nucleotide variant, known as rs117316434(A), results in a shortened protein being translated from the CCDC201 gene, which is highly expressed in egg cells.…
Published on August 23, 2024
Bayer’s non-hormonal drug elinzanetant, designed to treat hot flashes experienced by women during the menopause, has now achieved good Phase III results in three clinical trials. The German pharma company submitted a New Drug Application to the FDA earlier this month based on these results and plans to submit additional…
Published on May 20, 2024
The non-hormonal menopause therapy market may get a boost soon as Bayer’s elinzanetant met primary and secondary endpoints in two pivotal Phase III trials. The drug significantly reduced the frequency and severity of moderate to severe vasomotor symptoms (VSM), commonly known as hot flashes, in post-menopausal women. Neurokinin receptors help…
Published on April 4, 2024
A link has been established between earlier menopause, higher risk of cardiovascular disease (CVD), and cognitive problems later in life, in a new study published in Neurology. These Canadian researchers looked at whether age at menopause, vascular risk, and history of hormone therapy (HT) containing estrogens together influence cognition over…
Published on June 29, 2023
Hormone replacement therapy (HRT) is linked with dementia in later life, even if just taken for a short time around the start of menopause, a nationwide Danish study suggests. Results from the large, observational study contradict randomized trials suggesting no effect on cognitive function for women assigned to HRT during…
Published on February 1, 2023
Post-menopausal women with a higher cumulative exposure to estrogen have reduced risk for stroke compared to those with lower exposure, show results from a China Kadoorie Biobank study. Taking factors such as reproductive life span (from first menstruation to menopause), use of oral contraceptives, number of births, and length of…
Published on August 5, 2021
A large international study has revealed almost 300 genetic variants associated with early or late menopause, mostly linked to DNA damage response. In an experimental study in mice, the researchers also found that they were able to extend reproductive span in the animals by manipulating the DNA damage response pathway,…
Published on September 3, 2024
Taking hormone replacement therapy (HRT) appears to slow biological aging, according to a new study by Chinese researchers that included more than 100,000 women participants from the UK Biobank. The study found that postmenopausal women with historical hormone therapy (HT) use were biologically younger than those not receiving the treatment.…
Published on August 5, 2024
Hormones play a big role in our day-to-day health, and this is particularly relevant for women’s health, whether in relation to contraception, fertility, menstrual or endocrine problems, or menopause. However, hormone levels are rarely measured by healthcare professionals and accessing data about hormone levels to make decisions about their health…
Published on February 14, 2024
A study of people with homozygous familial hypercholesterolemia, a rare inherited condition causing high cholesterol, shows men seem to be at higher risk of cardiac events such as heart attack as a result of their condition than women with the same disease. The research, published in JAMA Cardiology, showed that…
Published on December 21, 2023
Biological sex and gender have a large impact on the presentation of a disease, its progression, and how it is treated, but these factors have not received adequate research or clinical attention. Positive signs of change are emerging, but there is a lot that needs to be achieved before these…
Published on December 20, 2023
Women’s health is chronically underfunded both in the public and private sectors and has been for many years. No one knows this better than Piraye Yurttas Beim, CEO and founder of Celmatix, a women’s health biotech company focused on improving ovarian health. Since founding Celmatix in 2009, she has been…
Published on August 9, 2023
A machine learning model can use background parenchymal enhancement (BPE) on breast MRI as an indicator of breast cancer risk in women with extremely dense breasts, according to a new study published in Radiology. “This is the first study that we know of that demonstrates an association between background parenchymal enhancement…