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Published on April 23, 2024
A research team in Spain, reporting in the Journal of the American College of Cardiology, say they have identified five subtypes of dilated cardiomyopathy (DCM), and created the first risk stratification of disease development among symptom-free people who carry a genetic mutation that can cause it. Estimates suggest that in…
Published on March 28, 2024
A study to be presented at the American College of Cardiology’s Annual Scientific Session found that young adults who were prescribed stimulant medications for attention deficit/hyperactivity disorder (ADHD) were more like to develop cardiomyopathy—a weakened heart muscle—compared with young adults who were not prescribed them. In particular, the study showed…
Published on January 25, 2024
Researchers at the Mayo Clinic investigating factors related to recovery from dilated cardiomyopathy have identified a variant in a specific gene that plays a role in people who recover from the condition and those who don’t. Results of the genome-wide association study (GWAS), published in Circulation Research, is expected to…
Published on July 17, 2023
BridgeBio’s candidate therapy for the rare disease transthyretin amyloid cardiomyopathy met its primary endpoint, according to results from a 30-month Phase III trial. The findings showed 81% of participants taking the drug candidate acoramidis were alive at 30 months versus 74% of the placebo group. The therapy also cut cardiac-related…
Published on February 2, 2022
A research study, led by the Ohio State University Wexner Medical Center, reveals the genetic nature of many cases of the heart muscle disorder dilated cardiomyopathy (DCM) and shows that Black families seem to have higher rates of inherited DCM than families of other ethnicities. Writing in JAMA, the research…
Published on February 1, 2021
Scientists from the University of Pennsylvania have discovered how mutations in the LMNA gene cause a congenital form of dilated cardiomyopathy, a serious heart condition that can be fatal. The researchers found that LMNA gene mutations have a particularly adverse effect on cardiac muscle cells compared to other cell types,…
Published on January 27, 2020
Researchers at Harvard may have discovered the molecular basis that can lead to cardiomyopathy in patients, as well as a new drug to treat this genetic conditions. Cardiac cells, also known as cardiomyocytes, are unique muscular cells in the body, in that they will repeatedly contract, without rest, over the…
Published on June 27, 2024
Combining rare genetic variants for atrial fibrillation (AF) with a polygenic risk score flags up considerable risk for this common heart arrhythmia, research shows. The findings in more than 400,000 people provide an insight into the genetics underpinning AF and could aid future genetic risk stratification. They suggest both rare…
Published on June 24, 2024
RNA therapeutics specialist Alnylam reports positive Phase III results for its RNA interference (i) therapy vutrisiran for treatment of the heart condition transthyretin amyloid cardiomyopathy (ATTR-CM). There are different types of amyloidosis, where abnormal proteins build up in different organs around the body. People with ATTR-CM have a build up…
Published on April 24, 2024
Heart disease in women is underdiagnosed compared to men. Now, more accurate cardiovascular risk models for women have been developed by U.S. and Netherlands researchers using a dataset of more than 20,000 participants in the UK Biobank. This team also quantified the underdiagnosis of heart disease in women. They say…
Published on April 10, 2024
Coronary artery disease and major depression may be genetically interconnected via inflammatory pathways, according to researchers at the Vanderbilt University Medical Center (VUMC) and the Massachusetts General Hospital (MGH). They used transcriptome-wide association scans to map single nucleotide polymorphisms involved in regulating the expression of genes associated with both CAD…
Published on March 28, 2024
Brain blood vessel damage that increases the risk of stroke and dementia is common in people with a range of heart conditions, regardless of whether they have experienced a stroke, a new study shows. The team’s findings could help in choosing appropriate treatments for these patients, said lead author Zien…
Published on March 13, 2024
The majority of adults who have survived childhood cancer are not up to date with potentially life-saving surveillance screening tests to check for delayed effects of their initial treatment, Canadian research suggests. The study, which included data for 3241 individuals diagnosed with cancer at one of Ontario’s five pediatric cancer centers…
Published on January 25, 2024
Researchers have found that the eye can provide a window into many different diseases, with thinner retinal layers having a genetic basis and an association with ocular and cardiometabolic diseases as well as neuropsychiatric conditions. The findings suggest that markers for systemic and ocular health could be developed from optical…
Published on January 22, 2024
On the heels of success for its new heart drug (acoramidis) in Phase III, BridgeBio Pharma has raised up to $1.2B from Blue Owl Capital and Canada Pension Plan Investment Board (CPP Investments). BridgeBio expects acoramidis will launch soon and become the “potential backbone of therapy for transthyretin amyloid cardiomyopathy…