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Published on September 18, 2024
The Keck School of Medicine of USC has announced the launch of a nationwide longitudinal study aimed at understanding how type 1 diabetes impacts brain development in children. Funded by a $2.7 million grant from the National Institutes of Health, this multi-site study will involve collaboration among 12 research centers…
Published on August 12, 2024
There is a team readily available to report 24/7 to a facility at the University of Chicago Medical Center to quickly receive and process a deceased donor’s pancreas into isolated islets for infusion into a patient with type 1 diabetes. The results have been astounding. Some patients who underwent allogeneic…
Published on July 16, 2024
Research led by Helmholtz Munich in Germany showed COVID-19 infection in high-risk young people almost doubled the rate of progression to type 1 diabetes during the pandemic compared with those who were not infected with the virus. The pandemic showed that COVID-19 increased the risk of diabetes. A systemic review…
Published on June 25, 2024
Promising new data from a trial of Vertex’s early phase islet cell therapy VX-880 for type 1 diabetes (T1D) trial showed three patients, with 12 months of follow-up, reached insulin independence. All of the dozen patients in the trial showed improvement over all—they received the full dose of VX-880 and…
Published on May 23, 2024
Researchers at City of Hope have discovered new biomarkers that could predict kidney failure in patients with type 1 diabetes (T1D), according to a study published today in Science Translational Medicine. The study, led by Rama Natarajan, PhD, deputy director of the Arthur Riggs Diabetes & Metabolism Research Institute at…
Published on January 5, 2024
Results from a large Finnish study show that women with type 1 diabetes are almost four times more likely to have a baby with a congenital heart defect (CHD) than those without diabetes. This association confirms previous research showing a link between maternal type 1 diabetes and CHDs in offspring.…
Published on December 6, 2022
The Parkinson’s disease medication bromocriptine, which increases dopamine levels in the body and has been reported to improve insulin sensitivity, reduces blood pressure and improves artery health in young people with type 1 diabetes. The research, led by the Heart Institute at the Children’s Hospital Colorado and published in the…
Published on November 18, 2022
U.S. regulators have approved Tzield (teplizumab-mzwv) as the first-ever treatment to delay the onset of clinical Type 1 diabetes (T1D). The decision by the U.S. Food and Drug Administration was hailed by diabetes experts as “a historic moment” and “the start of a seismic shift” in how T1D is treated.…
Published on September 23, 2022
A study suggests that type 1 diabetes is substantially more likely to develop in children who have had COVID-19 rather than other respiratory infections, raising concerns over long-term autoimmune complications from the SARS-CoV-2 virus. The analysis in more than half a million electronic health records in children aged 18 years…
Published on June 29, 2022
Researchers at the University of Chicago observed the role of beta cells in triggering autoimmunity, and found that knocking out a proinflammatory gene in the beta cells of mice genetically predisposed to develop T1D preserved beta cell mass and protected the animals from developing diabetes. The research findings also raise…
Published on June 8, 2022
Researchers at Imagine Pharma, a regenerative medicine company based in Pittsburgh, Philadelphia, have engineered pancreatic cells from someone with long term type 1 diabetes and enabled them to produce insulin. While the work is still in its early stages, if validated it could allow a patient’s own cells to be…
Published on March 22, 2022
An artificial intelligence (AI)-driven study led by the University of Missouri-Columbia discovered notably differences between those with familial and sporadic type 1 diabetes, with familial cases having many more comorbidities than patients with no family history of the condition. Type 1 diabetes is known to have both genetic and environmental…
Published on March 1, 2022
University of Pennsylvania School of Medicine researchers show that during the development of type 1 diabetes (T1D), the cells lining the pancreatic duct reprogram themselves in an attempt to suppress autoimmune T-cell responses that cause the autoimmune disorder. In T1D, immune cells called T lymphocytes attack and destroy insulin-secreting pancreatic…
Published on January 18, 2022
A team of researchers has discovered a technique to make immunomodulation after pancreatic islet transplantation more effective using nanocarriers to re-engineer the commonly used immunosuppressant rapamycin. Islet transplantation has emerged over the past few decades as a potential cure for type 1 diabetes. However, transplantation efforts have faced setbacks, as…
Published on July 23, 2021
An international group of researchers has carried out what they say is the “largest and most diverse” genetic study of type 1 diabetes to date that has allowed them to identify new causal variants and potential drug targets for new therapies. The study found 12 genes linked with type 1…