1980 Results
Sort By:
Published on July 6, 2016
A research team led by scientists at the University of Leuven in Belgium and the Pasteur Institute in France has found that a bacteriophage infecting an opportunistic and clinically relevant bacterium metabolizes host RNA to replicate itself inside the cell. The findings were published recently in PLOS Genetics through an…
Published on July 4, 2016
The contribution of individual cells to aggregate phenotypes is of increasing interest in biology, as is evident in the rise of technologies that can resolve cell-level details from the blur of population-level generalities. Among these technologies is RNA sequencing (RNA-seq), which can take snapshots of the transcriptome, capturing fleeting expression…
Published on July 1, 2016
Sponsor: Oxford Gene Technology The SureSeq™ FFPE DNA Repair Mix is optimized to restore a broad range of damage in formalin-fixed, paraffin-embedded (FFPE) derived DNA. The mix effectively repairs DNA damage, improving library yields, on-target rates, and mean target coverage, while removing fixation and storage artifacts and reducing the amount…
Published on June 27, 2016
Investigators at the Medical University of South Carolina (MUSC) have recently identified unique functional oncogene signatures in four different human breast cancer cell types. The new study—“Functional oncogene signatures guide rationally designed combination therapies to synergistically induce breast cancer cell death”—which was published recently in Oncotarget may soon aid physicians…
Published on June 16, 2016
Understanding how the gut microbiome is established and by what means the combination of microbes in individual children may contribute to the risk of developing conditions like type 1 diabetes and inflammatory bowel disease is key to overall developmental health. Now, a research team led by investigators at Massachusetts General…
Published on June 10, 2016
After the initial diagnosis of cancer, the next morbid news patients must deal with is the approximation of life expectancy and how well they can expect to respond to chemotherapeutic interventions. These estimates are historically based on precedents set by previous cancer patients. Yet, what if there were a way…
Published on June 9, 2016
A new study led by researchers at Children's Hospital Los Angeles (CHLA) and the Genetic Disease Screening Program of the California Department of Public Health may have shed new light on the 1,800 genetic mutations associated with Cystic fibrosis (CF) that remain uncategorized. CF is a progressive, inherited, autosomal recessive…
Published on June 6, 2016
Cancer immunotherapy has ignited a firestorm of new drug compounds that target novel tumor markers that activate patients’ immune system to destroy various cancer cell types. These therapies have provided remarkable success; however, they are expensive to produce and administer, with a percentage of patients showing little to no therapeutic…
Published on June 2, 2016
The results from a unique new pilot program conducted by scientists from the Icahn School of Medicine at Mount Sinai show that multidimensional genomic profiles outperform the targeted cancer panels used currently in many clinical laboratories. The Mt. Sinai team developed and tested the personalized cancer therapy program using an…
Published on June 2, 2016
The argument among scientists as to whether there are some inheritable gene mutations for multiple sclerosis (MS) may have just come to an end due to new data from a recent study published by researchers at the University of British Columbia (UBC) and Vancouver Coastal Health. The investigators were able…
Published on June 2, 2016
With $215 million in funding, the federal government’s Precision Medicine Initiative® is expected to generate the scientific evidence needed to move personalized medicine into clinical practice by providing clinicians with the knowledge and tools to determine more precise medical treatment. One objective of the initiative is to accelerate pharmacogenomics (PGx),…
Published on June 1, 2016
Sponsor: Active Motif The new ChIP-exonuclease (ChIP-exo) Kit offers a highly optimized protocol for high-resolution genome-wide mapping of transcription factor binding sites. ChIP-exo is a modified ChIP-Seq approach that utilizes exonuclease digestion to reduce DNA fragments to the site of transcription factor binding prior to deep sequencing. The advantage of…
Published on May 25, 2016
A new study led by researchers at The University of Texas MD Anderson Cancer Center has uncovered genetic mutations that could potentially fuel early cancer growth in precancerous colorectal tissue from high-risk patients. This is the first study to use whole-exome sequencing (WES) to characterize genetic changes in precancerous polyps…
Published on May 24, 2016
Identifying the genetic backgrounds that provide innate protection to maladies such as cancer, infectious diseases, or cardiovascular disorders is paramount to developing appropriate therapies to treat the majority of afflicted patients who suffer from these ailments. Now, an international team of researchers has focused their attention on elucidating the complex…
Published on May 20, 2016
Often called degenerative joint disease or “wear and tear” arthritis, osteoarthritis (OA) is the most common chronic condition of the joints. It occurs when the cartilage or cushion between joints breaks down leading to pain, stiffness, and swelling. Joint injury may result in posttraumatic osteoarthritis (PTOA). In fact, about half…