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Published on April 1, 2016
Sponsor: DeNovix The new dsDNA fluorescence kit enables sub-picogram concentration fluorescence quantification for single-cell, ChIP-Seq, laser dissection, and other low sample input genomics applications. This Ultra High Sensitivity dsDNA assay brings a 20-fold improvement in sensitivity over commonly used assays, allowing detection between 0.5 and 300 pg/µL to rapidly quantify…
Published on April 1, 2016
Sponsor: Fluxion Two new kits were recently released for enhanced circulating tumor cell (CTC) isolation and recovery and that are designed to work exclusively with the IsoFlux Liquid Biopsy system. The Enhanced Recovery kit adds EGFR to the traditional EpCAM antibody, and the EMT kit includes EpCAM, EGFR, and two…
Published on March 31, 2016
As breast cancer specialist George Sledge, M.D., said in his presentation at the Personalized Medicine World Conference last year, “It turns out that we don’t need a magic bullet to cure cancer. We need a magic shotgun.” Dr. Sledge, professor and chief of medical oncology at Stanford University Medical Center, was referring…
Published on March 28, 2016
The enormous diagnostic potential to dramatically change clinical medicine that is contained within the technique known as liquid biopsy has ignited a flurry of ideas and designs within the molecular diagnostic field. The ability to take a minimally invasive biological sample from a patient and diagnose or track disease could…
Published on March 25, 2016
Scientists at University of Oxford and the Evandro Chagas Institute in Brazil have reported on the sequencing of seven Zika virus (ZIKV) genomes from the recent South American outbreak, including one fatal adult case and one newborn with microcephaly. This data offers new information on how and when the virus…
Published on March 22, 2016
It’s not an either/or situation. Both DNA sequencing and RNA sequencing hold clinical promise—diagnostically, prognostically, and therapeutically. It must be said, however, that RNA sequencing reflects the dynamic nature of gene expression, shifting with the vagaries of health and disease. Also, RNA sequencing captures more biochemical complexity, in the sense…
Published on March 21, 2016
Origin Technologies said today its unsolicited offer to acquire Affymetrix for approximately $1.5 billion still stands despite a rebuff yesterday from Affymetrix’s board. Origin, a new entity created by a group of former Affymetrix executives, disclosed its all-cash offer on Friday. At $16.10 per share, Origin’s proposal exceeds the $14…
Published on March 9, 2016
It’s a first—a study that tracks antimicrobial use and resistance through the entire beef production process. And it has surprising results. First, an examination of samples from 1741 cattle yielded no resistance genes. Second, an examination of environmental samples from cattle pens revealed the presence of genes that confer resistance…
Published on March 7, 2016
A blood test may be able to sound early warning bells that patients with advanced melanoma skin cancer are relapsing, according to a study (“Application of Sequencing, Liquid Biopsies and Patient-Derived Xenografts for Personalized Medicine in Melanoma”) published in Cancer Discovery. Scientists from the Cancer Research UK Manchester Institute studied…
Published on March 1, 2016
The world’s first processor expressly designed to perform secondary analysis of next-generation sequencing data is relieving the bottleneck between sequencing and practical application. Setting a new standard for speedy analysis, the processor recently allowed a provider of clinical sequencing services to analyze sequenced genomes in just 26 minutes. Moreover, it…
Published on March 1, 2016
Targeted sequencing is an economical way to obtain sequencing reads that are limited only to genomic regions of interest. There are two different approaches used in targeted sequencing—exome capture and amplicon sequencing.1,2 While exome capture has advantages for whole-exome sequencing (30 Mb for the human genome), amplicon libraries offer more…
Published on March 1, 2016
The influence that the polymerase chain reaction (PCR) has had on modern molecular biology is nothing short of remarkable. This technique, which is akin to molecular photocopying, has been the centerpiece of everything from the OJ Simpson Trial to the completion of the Human Genome Project. Clinical laboratories use this…
Published on February 29, 2016
Over half a century ago, Conrad Hal Waddington introduced his model of the epigenetic landscape. He depicted a differentiating cell as a ball rolling down a landscape of bifurcating valleys and ridges, with each valley representing an alternative developmental path. Just as a ball may roll from valley to valley…
Published on February 29, 2016
Clinical actionability, or the determination of whether clinical action should be taken based on heterogeneous information generated by cancer genomic analysis, remains a key challenge for scientists and clinicians. Rodrigo Dienstmann, M.D., et al., writing in Molecular Oncology in 2014 (“Standardized decision support in next generation sequencing reports of somatic…
Published on February 25, 2016
The NIH has selected Vanderbilt University and Verily (formerly Google Life Sciences) to launch the first “pilot” phase of the Precision Medicine Initiative (PMI)'s planned research cohort of 1 million or more Americans from which to glean health and wellness data. The Vanderbilt-Verily partnership was announced today by President Obama's…