A new study by an international team of scientists lead by researchers at Columbia University Medical Center (CUMC), and New York-Presbyterian has just found that several genes previously implicated only in rare, severe forms of pediatric epilepsy also contribute to common forms of the disorder. The findings from the study…

Analyzing complex gene networks can be as easy as one, two, three. One: Introduce CRISPR-based perturbations to large numbers of cells. Two: Measure the effects of these perturbations with single-cell RNA sequencing. Third: Dissect the genetic pathways that link genotype and phenotype. By following these steps, researchers can explore the…

Scientists at the Translational Genomics Research Institute (TGen) have just published evidence suggesting that survival from glioblastoma (GBM), an aggressive and deadly form of brain cancer, could be determined by the complexity of their tumor. The findings from this new study, which were published recently in Neuro-Oncology through an article…

Global health technology company Royal Philips announced it is teaming up with molecular clinical decision support company N-of-One to enhance the capabilities of Philips’ IntelliSpace Genomics solution. Under the terms of the agreement, the companies will collaborate to provide healthcare organizations with clinical analysis, annotation and interpretation of genomics, and…

Weill Cornell Medicine (WCM) and the New York Genome Center (NYGC) announced the award of a National Cancer Institute grant of $2.45 million over five years for the organizations to develop a cancer genomics data center to support research and clinical interpretation of tumors. The joint center will perform computational…

Sifting for clues to cancer by combining genomic and clinical data is the goal of a new information platform launched today by healthcare technology developer Flatiron Health and oncology-focused molecular information company Foundation Medicine. The companies have co-developed the Clinico-Genomic Database, an information platform designed to help researchers and biopharmas speed…

In late 2013, the FDA published Paving the Way for Personalized Medicine: FDA’s Role in a New Era of Medical Product Development, with the intention of describing the agency’s goals to help drive personalized treatments and diagnostics. Within the introduction it is stated that “elegant science” and “well-designed” personalized medicine…

Caris Life Sciences and cancer-focused biopharma company Threshold Pharmaceuticals announced a development and commercialization agreement that will see the companies use Caris’ ADAPT Biotargeting System to develop a tissue-based clinical diagnostic assay to predict the likelihood of response to evofosfamide, Threshold’s lead drug candidate. Under the terms of the agreement,…

A new study being conducted by Sanford Health is currently enrolling patients to determine how genomic profiling could help improve treatment options for patients with advanced, or rare forms of cancer. The Community Oncology use of Molecular Profiling to Personalize the Approach to Specialized cancer treatment at Sanford (COMPASS) trial,…

The principle underlying molecular diagnostics is simple—devise a methodology that quickly detects an altered state through the analysis of a biological marker. With that philosophy in mind, companies go to great lengths to develop sophisticated equipment that will accurately measure either a single or collection of biomarkers that are known…

Researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have identified 14 genes that regulate genomic integrity, which were consistently overexpressed in a wide variety of cancers. In the new study—“Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy”—which was published…

The department of pathology at the Icahn School of Medicine at Mount Sinai Hospital recently launched  the Center for Computational and Systems Pathology, with the goal of revolutionizing pathology practice via the use of advanced computer science and mathematical techniques coupled with cutting-edge microscope technology and artificial intelligence. The academic…

Scientists at the University of Hawaii Cancer Center say they have developed a computational algorithm to analyze big data obtained from tumor samples and thus understand and treat cancer better. “A growing problem in cancer research is figuring out how to analyze the many kinds of big genomic data for…

A new study led by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) has uncovered an unforeseen process in the acquisition of drug resistance by cancer cells that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1…

Researchers at the Sanford-Burnham Prebys Medical Discovery Institute (SBP) have uncovered more than 100 new genetic regions that affect the immune response to cancer. The recent findings—“Mutation drivers of immunological responses to cancer”—published in Cancer Immunology Research, could assist scientists in the development of future treatments that enhance the immune…