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Published on July 6, 2020
Once an ecosystem is disturbed, restoring it can be difficult. And when the disturbed ecosystem is a patient’s microbiome, restoring the patient to health can be even more difficult. Just one ecosystem element that proliferates or diminishes beyond bounds may throw multiple elements into disarray, creating a dysbiosis that resists…
Published on June 15, 2020
Molecular diagnostics for everything from cancer testing to what medications doctors should prescribe—or not prescribe—for heart disease, mental health and a host of other conditions have been steadily increasing their share of the diagnostics pie over the past five years. That was until COVID-19 and the subsequent, ongoing global pandemic…
Published on November 7, 2019
PredictImmune said today it is partnering with the Crohn’s & Colitis Foundation to jointly fund and launch a clinical study designed to validate the company’s PredictSURE IBD biomarker, which if approved would be the first prognostic test for inflammatory bowel disease (IBD) authorized in the U.S. The PRECIOUS Study: Predicting…
Published on November 7, 2019
Single cell analysis, CRISPR, glycomics, and other advanced technologies are making it possible to finally uncover the root causes of autoimmune diseases and possibly diagnose and treat them earlier. One of the most difficult questions in all of medical science today is “Why do immune cells turn against the body…
Published on May 30, 2019
A multi-omic study of the microbiome by researchers from Harvard T.H. Chan School of Public Health and the Broad Institute of MIT and Harvard has provided a comprehensive view of functional dysbiosis in the gut microbiome during inflammatory bowel disease (IBD). The new study, by participants in the second phase…
Published on March 5, 2019
Mouth ulcers or as they are often colloquially referred, canker sores, affect up to 25% of young adults and a higher proportion of children. Many causes of mouth ulcers have been previously identified including mucosal trauma and a range of autoimmune and inflammatory conditions, such as Crohn’s disease, lupus, and…
Published on February 6, 2019
The results of a genome-wide meta-analysis of genetic data from more than two million individuals has linked 102 genetic variants and 269 genes with depression, and found associations between the psychiatric disorder and a number of behavioral traits. The researchers, headed by a team at the University of Edinburgh, say…
Published on February 5, 2019
The gut/brain connection grew much stronger this week with the publication of the first population-level study on the link between gut bacteria and mental health. The research identified specific gut bacteria linked to depression and provides evidence that a wide range of gut bacteria can produce neuroactive compounds. The study,…
Published on January 31, 2019
Microbial genomics company uBiome has awarded researchers at Stanford University a grant to study the role of abnormal semen microbiome in infertility. The goal of the study—led by Professor of Obstetrics and Gynecology, Barry Behr, Ph.D., and Sara Vaughn, M.D., a fellow in reproductive endocrinology and infertility—is to analyze the…
Published on January 10, 2019
Diets containing berries and pomegranates are believed to have potentially manifold benefits to human health, and scientists in India and the U.S. have now demonstrated in mice how one pomegranate-derived metabolite that is produced by microorganisms residing naturally in the gut can help to protect against and reduce the severity…
Published on June 6, 2018
Microbiotica said today it will use its precision metagenomics microbiome platform in an up-to-$534 million-plus multi-year partnership with Genentech, a member of the Roche Group, to discover, develop and commercialize microbiome-based biomarkers and therapies for inflammatory bowel disease (IBD). Microbiotica, a Wellcome Trust Sanger Institute spinout, said the platform allows…
Published on October 3, 2017
New data from members of the NIH's Human Microbiome Project (HMP) at the University of Maryland School of Medicine (UM SOM), Harvard T.H. Chan School of Public Health, the Broad Institute of MIT and Harvard, and the University of California San Diego have uncovered millions of previously unknown genes from…
Published on July 12, 2017
Enterome and Nestlé Health Science have teamed up to create a joint venture focused on developing novel microbiome-based diagnostics for areas that include inflammatory bowel diseases (IBD) and liver diseases. Microbiome Diagnostics Partners (MDP) will combine Enterome’s microbiome diagnostic programs and intellectual property (IP) in all therapeutic areas except immuno-oncology,…
Published on March 2, 2016
Pathologists use tissue biopsy as the gold standard for definitively diagnosing an array of diseases, such as cancer, kidney disease, or inflammatory disorders like Crohn’s disease. Typically, physicians can only take two-dimensional (2D) snapshots of the tissue, and they are limited in their ability to measure protein levels that might…
Published on June 2, 2015
Sift through metadata. Track contact activity. Identify suspicious patterns. This to-do list sounds as though it were devised by the National Security Agency. But it actually describes a research plan enacted by a group of genomic scientists in Japan and the United Kingdom. The scientists sifted through a catalogue of…