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Published on February 14, 2020
Researchers at Columbia University Department of Biomedical Engineering have engineered a novel probiotic strain of bacteria that can safely deliver immune checkpoint inhibiting nanobodies directly to tumors. When tested in cancer-bearing mice, a single dose of the bacteria continuously produced and released the anti-PD-L1 and anti-CTLA-4 nanobodies, triggering an immune…
Published on February 14, 2020
Belgian precision oncology company OncoDNA said today it has completed a €19 million ($20 million) Series B equity financing designed to support rapid international growth, accelerate software development, and carry out hiring initiatives. OncoDNA said it has begun rolling out its OncoKDM cancer-focused clinical decision support software, a web-based tool…
Published on February 13, 2020
The coming decade is guaranteed to bring a panoply of emerging fields will help us better understand the intersection between genetics and health and how to incorporate them into routine medical practice. Polygenic risk scores (PRS) is, perhaps, at the top of the “must watch” list. With a firm footing…
Published on February 7, 2020
Sponsored content brought to you by As genome sequencing technology advances, researchers are increasingly exploring emerging tools for a host of potential clinical applications. Andrew Beggs of the University of Birmingham is one of those pioneers. A surgeon as well as a researcher in cancer genetics, Beggs recently described several…
Published on February 7, 2020
Sponsored content brought to you by What if every patient’s oncologist or lab testing personnel had access to an online digital encyclopedia of cancer mutations, associated therapies, and available clinical trials? Now they can, with The Clinical Knowledgebase (CKB), powered by The Jackson Laboratory (JAX). The advent of DNA…
Published on February 7, 2020
Now 15 years old, the Personalized Medicine Conference held every November in Boston has been a year-ending touchpoint for leaders in the field to assess recent advances, but also to grapple with the issues slowing the adoption of personalized treatments for patients. While keynote speeches on each day from CAR-T…
Published on February 7, 2020
There is typically much reflection whenever tipping from one decade into the next, as we look back at what has transpired over the past 10 years. When it comes to omics technologies and their application to precision medicine, there have certainly been significant advances. Notable among them would be the…
Published on February 5, 2020
Screening a fetus for genetic abnormalities is not a new idea or technology, but a new single-cell prenatal blood test can make this experience an easier and safer procedure. A new assay developed by Kenichiro Hata and colleagues in Japan has completed its first clinical experiment, and published a proof-of-concept…
Published on January 28, 2020
A new analysis of available data has convinced a panel genomic experts that nine genes previously believed to be associated with a rare, genetic heart condition—long QT syndrome—were an erroneously linked to the condition, as revealed in a new study funded by the National Human Genome Research Institute (NHGRI), a…
Published on January 21, 2020
Researchers in Boston might have hit a gold mine when it comes to cancer treatment—instead of creating new chemical compounds to treat cancer cells, they have taken thousands of pre-existing drug compounds designed to treat other illnesses and screened them for their effects on cancer. Nearly 50 of these medications…
Published on January 17, 2020
Nucleic acid developer and manufacturer Integrated DNA Technologies (IDT) announced this week it was expanding it global partnership with genomic and radiomic analysis company SOPHiA Genetics to bundle IDT’s kits and reagents with the SOPHiA analytic platform. “Our strong relationship with IDT has enabled us to further accelerate the democratization…
Published on January 16, 2020
Next-generation sequencing based cancer diagnostics company Personal Genome Diagnostics (PGDx) announced a partnership agreement with pharmaceutical company Eisai Co., to develop a liquid biopsy test to be used by researchers at Eisai’s Tsukuba Research Laboratory. Under the terms of the agreement, the two companies will look to develop a kitted…
Published on January 15, 2020
Researchers have discovered a new gene interaction mechanism that leads to metastasis in cancer cells: pro-oncogenes MYC and TWIST1. Using a mouse model, scientists have found that when these two transcription factors interact in tumor cells, they create an environment that co-opts immune cells, and allows tumor cells to metastasis throughout…
Published on January 15, 2020
One for liquid biopsies, another for tissue biopsies. That’s the tack Pharma giant Amgen is taking with its dual announcements this week detailing new partnerships with Guardant Health and Qiagen related to develop a liquid biopsy companion diagnostic (CDx) and a tissue based CDx, respectively, for its investigational cancer treatment…
Published on January 14, 2020
Clinical laboratory and drug development services company LabCorp said today that it will use Thermo Fisher Scientific’s new Ion Torrent Genexus System with the Oncomine Precision assay for the development of companion diagnostics and other oncology and precision medicine applications in the future. As part of the deal, LabCorp will…