93 Results
Sort By:
Published on August 12, 2024
People in the U.S. have access to thousands of FDA-approved drugs, yet millions live with conditions that have no registered treatments and are faced with shortened life spans as a result. While pharmaceutical companies invest billions of dollars and years of time developing new medications, the FDA typically only approves…
Published on December 26, 2023
A study involving 381 children has linked cognitive function with the enrichment or depletion of certain species of gut microbes. The findings are among the first to directly investigate associations between early brain development and specific gut bacteria, say lead author Kevin Bonham, of the Department of Biological Sciences at…
Published on October 13, 2023
Brain inflammation as a child can affect the development of two rare types of cerebellar neurons and could provide an insight into its role in conditions such as autism and schizophrenia. Researchers found that Purkinje and Golgi neurons were vulnerable to brain inflammation and showed premature disruption in their maturation.…
Published on February 14, 2023
Mental healthcare company Wellbeing Digital Sciences and its subsidiary KGK Science announced today it received an exemption under Canada’s Controlled Drugs and Substances Act to begin with its partner Nova Mentis Life Science. The company says this is the first-ever Phase IIa clinical trial assessing the efficacy of repetitive, oral…
Published on February 10, 2023
Researchers have identified 27 genetic risk loci for attention-deficit hyperactivity disorder (ADHD) and provided a window into how it relates to other psychiatric conditions. The genome-wide analyses revealed 21 new loci linked with the neurodevelopmental disorder and found that it was influenced by thousands of genetic variants. The vast majority…
Published on January 12, 2023
In a multimillion-dollar Swiss deal, precision molecular science biotech Stalicla has gained worldwide rights from Novartis to progress the experimental drug mavoglurant for substance-use and neurodevelopmental disorders. The exclusive, in-licensing agreement includes undisclosed up-front fees, equity and up to $270M in development and commercial milestones, with additional royalties on sales.…
Published on November 7, 2022
Results from a study led by Boston Children’s Hospital show that chromosomal microarray analysis could be a helpful additional test in cases of unexplained sudden infant death syndrome (SIDS). The study, published in Advanced Genetics, shows that around 12 percent of such cases could be due to copy number or…
Published on November 4, 2022
Australian scientists have developed a world-first map showing gene activity changes in diverse human brain cell types from pre-birth to adulthood. This map of normal brain cell development should help researchers identify altered states more accurately in neurological and psychiatric disorders such as schizophrenia, or aberrant cell states in diseases…
Published on October 14, 2022
Recent research demonstrating how important the human microbiome is for maintaining good health has led to the founding of many biotech companies hoping to create microbiome-based therapeutics. These five biotech companies all have candidates in clinical trials and are primed to be among the first to receive market approval. The…
Published on July 14, 2022
Researchers at the Children’s Hospital of Philadelphia’s (CHOP) Center for Applied Genomics (CAG) have developed an algorithm using existing electronic health records (EHRs) is able to distinguish patients with attention deficit/hyperactivity disorder (ADHD) alone from other related conditions. The researchers hope the new tool can be applied in broader clinical…
Published on May 9, 2022
A new genotype has been found that increases the recurrence of extreme nausea and vomiting during pregnancy, a condition called hyperemesis gravidarum (HG). HG can cause serious illness, including starvation, which affects both the mother and fetus. Some mothers with this condition even terminate wanted pregnancies and many decide not…
Published on February 28, 2022
The Hospital for Sick Children (SickKids) in Toronto has announced that it will employ PacBio’s HiFi long-read, whole-genome sequencing (WGS) technology as a diagnostic tool to identify genetic variants that may be associated with undiagnosed medical and development conditions. The collaboration will use samples that have been previously subjected to…
Published on February 28, 2022
A new study has identified about a dozen saliva-based micro RNAs associated with gastrointestinal disorders in children with neurodevelopmental conditions, including autism. The researchers hope their findings could help one day lead to individualized treatments for such patients. The lead author is David Q. Beversdorf, a clinician at the University…
Published on January 5, 2022
Artificial intelligence drug design company Iktos, and South Korean clinical research biotech Astrogen announced today a collaboration with the goal of discovering small-molecule pre-clinical drug candidates for a specific, undisclosed, marker of Parkinson’s disease (PD). Under the terms of the agreement, whose value was not disclosed, Iktos will apply its…
Published on October 25, 2021
Nearly 40% of patients suffering from inflammatory bowel disease (IBD) also suffer from psychiatric disorders such as depression and anxiety. While the gut-brain axis is believed to drive these symptoms, the mechanisms have been unclear. Now, a new study from scientists at Humanitas University in Italy, shows the presence of…