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Published on October 11, 2023
A new AI tool called EVEscape developed by researchers at the Harvard Medical School (HMS) and the University of Oxford can predict new viral variants before they even emerge. Details of their study, published today in Nature, show that the tool has two elements. One models evolutionary sequences to predict…
Published on September 22, 2023
A team of researchers from the Universities of Geneva (UNIGE), Lausanne (UNIL), the Geneva University Hospitals (HUG) and the Vaud University Hospital (CHUV) in Switzerland have discovered how to prolong the functionality of CAR-T cells by inhibiting a specific metabolic mechanism. CAR-T cell immunotherapy, which involves taking immune cells from…
Published on September 20, 2023
A Phase II clinical trial being led by researchers at Dana-Farber Cancer Institute along with 10 brain tumor centers across the U.S. is taking an efficient and innovative method to find new potential treatments for glioblastoma. While the adaptive platform trial has not shown any of the three therapeutics tested…
Published on August 16, 2023
Developing individually-tailored immunotherapies is one of the highest aspirations of cancer researchers. Now, new work suggests deep-learning technology can accurately predict which cancer-related protein fragments—neoepitopes—are most likely to trigger an immune system response to a specific tumor. This tool could help in development of personalized immunotherapies and vaccines, according to…
Published on August 9, 2023
In 2012, 6-year-old Emily Whitehead’s acute lymphoblastic leukemia returned, and no traditional treatment options remained. So she became the first child to receive CAR-T immunotherapy, which engineered her T cells to fight the cancer. More than a decade later, Emily is cancer-free. Her success spawned new hope that immunotherapy could…
Published on August 8, 2023
William A. Haseltine, PhD Hepatitis C is a serious disease that affects more than 58 million people globally.1 Although endemic in many countries, it is possible to eliminate the disease within entire populations. Unfortunately, this has only been done in a limited number of countries. Here…
Published on June 12, 2023
New research from the Allen Institute and the Fred Hutchinson Cancer Center provides evidence that an overactive inflammatory response could be a root cause of many cases of long COVID. The study, published today in the journal Nature Communications, details the discovery of a set of molecules associated with inflammation…
Published on May 17, 2023
A team of researchers from USC Norris Comprehensive Cancer Center have identified a new biomarker that shows which patients with non-small cell lung cancer (NSCLC) will respond well to chemoimmunotherapy. The biomarker, CX3CR1, can be detected with simple blood test six to nine weeks after a patient has begun their…
Published on March 30, 2023
A newly created nanoparticle that carries a messenger RNA (mRNA) payload that can be administered to the lungs may offer a method to provide an inhalable treatment for cystic fibrosis and other lung diseases. Designed by engineers at MIT and the University of Massachusetts Medical School and applied in a…
Published on March 28, 2023
A team of researchers at the University of Helsinki, Finland, report they have developed a molecule that can be administered nasally to prevent the development of COVID-19 symptoms by all known variants of the SARS-CoV-2 virus. The team noted that the molecule could be a tool used in future pandemics…
Published on February 10, 2023
William Haseltine It is becoming increasingly clear that we have misunderstood SARS-CoV-2, the virus that causes COVID-19. Many people, including some experts in the scientific community, deemed the pandemic over with the release of the mRNA vaccines. The belief—or perhaps it was hope in disguise—was that…
Published on October 31, 2022
Encapsulating treatments into “protocells” in order to reprogram macrophage immune cells could be a promising strategy to fight cancers such as melanoma, according to research led by the University of Bristol. Certain micro-RNAs are linked with worse outcomes in cancer patients. In this study, which is published in Advanced Science,…
Published on October 20, 2022
McGill University is launching the Victor Phillip Dahdaleh Institute of Genomic Medicine with gifts totaling more than $30 million from the owner and chairman of Dadco, a privately owned investment, manufacturing, and trading group. “Dahdaleh’s generous gift provides crucial resources to help us attract impactful young scientists, students and trainees from…
Published on October 14, 2022
The COVID-19 pandemic has turned RNA into a household word, but what new innovations and changes will we see in the RNA therapeutics space going forward and how many will actually reach the clinic? The last couple of years proved a turning point for biotech companies such as BioNTech and…
Published on September 22, 2022
The National Comprehensive Cancer Network (NCCN) released this morning significant revisions from its NCCN Advisory Committee on COVID-19 Vaccination and Pre-exposure Prophylaxis to include recommendations on the recently-approved bivalent vaccines as well as how to protect children with cancer. The new, evidence-based, expert consensus-formulated summary on cancer and COVID-19 vaccination…