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Published on January 17, 2017
An international collaboration led by researchers at the Wellcome Trust Sanger Institute has shown that truly personalized therapy will be possible in the future for people with cancer. Details of how a knowledge bank could be used to find the best treatment option for people with acute myeloid leukemia (AML)…
Published on January 6, 2017
Three years after co-founding Human Longevity Inc., J. Craig Venter, Ph.D., will step down as CEO, but will remain executive chairman of the company he helped form to develop and apply large-scale computing and machine learning to discoveries aimed at revolutionizing medical practice. Succeeding Dr. Venter as CEO will be Cynthia Collins, who…
Published on December 7, 2016
Scientists at the Translational Genomics Research Institute (TGen) have just published evidence suggesting that survival from glioblastoma (GBM), an aggressive and deadly form of brain cancer, could be determined by the complexity of their tumor. The findings from this new study, which were published recently in Neuro-Oncology through an article…
Published on November 16, 2016
Global health technology company Royal Philips announced it is teaming up with molecular clinical decision support company N-of-One to enhance the capabilities of Philips’ IntelliSpace Genomics solution. Under the terms of the agreement, the companies will collaborate to provide healthcare organizations with clinical analysis, annotation and interpretation of genomics, and…
Published on November 7, 2016
Weill Cornell Medicine (WCM) and the New York Genome Center (NYGC) announced the award of a National Cancer Institute grant of $2.45 million over five years for the organizations to develop a cancer genomics data center to support research and clinical interpretation of tumors. The joint center will perform computational…
Published on November 3, 2016
Sifting for clues to cancer by combining genomic and clinical data is the goal of a new information platform launched today by healthcare technology developer Flatiron Health and oncology-focused molecular information company Foundation Medicine. The companies have co-developed the Clinico-Genomic Database, an information platform designed to help researchers and biopharmas speed…
Published on October 25, 2016
Caris Life Sciences and cancer-focused biopharma company Threshold Pharmaceuticals announced a development and commercialization agreement that will see the companies use Caris’ ADAPT Biotargeting System to develop a tissue-based clinical diagnostic assay to predict the likelihood of response to evofosfamide, Threshold’s lead drug candidate. Under the terms of the agreement,…
Published on September 7, 2016
The principle underlying molecular diagnostics is simple—devise a methodology that quickly detects an altered state through the analysis of a biological marker. With that philosophy in mind, companies go to great lengths to develop sophisticated equipment that will accurately measure either a single or collection of biomarkers that are known…
Published on September 1, 2016
Researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have identified 14 genes that regulate genomic integrity, which were consistently overexpressed in a wide variety of cancers. In the new study—“Centromere and kinetochore gene misexpression predicts cancer patient survival and response to radiotherapy and chemotherapy”—which was published…
Published on July 21, 2016
A new study led by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH) has uncovered an unforeseen process in the acquisition of drug resistance by cancer cells that bypasses the need to re-establish DNA damage repair in breast cancers that have mutant BRCA1…
Published on July 19, 2016
Researchers at the Sanford-Burnham Prebys Medical Discovery Institute (SBP) have uncovered more than 100 new genetic regions that affect the immune response to cancer. The recent findings—“Mutation drivers of immunological responses to cancer”—published in Cancer Immunology Research, could assist scientists in the development of future treatments that enhance the immune…
Published on June 20, 2016
New research aimed at mapping the molecular mechanisms behind the early stages of bladder cancer has discovered that tumors of the disease can be divided into three primary classes, each with very different molecular and disease developing characteristics. The study's findings—presented by a team of researchers from Aarhus University in…
Published on June 8, 2016
AstraZeneca and Foundation Medicine recently announced a collaboration aimed at developing a companion diagnostic for cancer therapeutic Lynparza, AZ’s first-in-class poly ADP-ribose polymerase (PARP) inhibitor that exploits the DNA damage response (DDR) pathway deficiencies to preferentially kill cancer cells. Lynparza is currently approved by the FDA for BRCA-mutated advanced ovarian…
Published on May 10, 2016
Research teams from 39 institutions around the world collected and analyzed 91 samples of adrenocortical carcinoma (ACC)—hoping to improve our understanding about one of the rarest, and lethal, types of cancer. This comprehensive analysis was performed as part of The Cancer Genome Atlas (TCGA) Research Network. The investigators from this…
Published on May 9, 2016
An international team of researchers has uncovered a multitude of new driver mutations in lung cancer cells that may be responsive to genomically targeted and to immune cell therapies. “We have identified several distinct recurrent mutations that are likely to be recognized by the immune system and therefore would be…