A City of Hope-developed CAR T cell therapy has shown it is both safe and produced promising therapeutic activity in patients with metastatic castration resistant prostate cancer (mCRPC). Results of the Phase I clinical trial were published today in Nature Medicine. The study treated 14 patients with prostate stem cell…

The first patient has received a personalized vaccine in a clinical trial as part of NHS England’s new Cancer Vaccine Launch Pad. The plan is that thousands of patients in England will gain access to personalized cancer vaccine trials through the new “matchmaking” service for patients and drug developers. Thirty…

New data from the National Cancer Institute’s Molecular Analysis for Therapy Choice (NCI-MATCH) precision medicine clinical trial has shown in a Phase II study that the trastuzumab-pertuzumab combination therapy, already approved for the treatment of HER2-positive breast cancer, shrunk the tumors of several other cancer types. The findings warrant additional…

A large Swedish study has shown that people undergoing surgery for cancer have an increased risk for venous thromboembolism (VTE) that persists for about two to four months postoperatively but varies by cancer type. “The results highlight the need for individualized venous thromboembolism risk evaluation and prophylaxis regimens for patients…

European cancer mortality predictions for 2024 highlight a concerning increase in colorectal cancer deaths among people aged 29–45 years that the researchers suggest is linked to increasing rates of overweight and obesity. For the 14th consecutive year, Carlo La Vecchia, professor of Medical Statistics and Epidemiology at the University of Milan…

Researchers led by teams at the Institute for Bioengineering of Catalonia (IBEC) and CIC biomaGUNE demonstrated how a single dose of urea-powered, radionuclide-carrying nanorobots successfully reduced the size of bladder tumors in mice by 90%. The researchers suggest that their results could pave the way for the development of new…

Researchers at the University of Texas at Austin (UT) have developed a drug able to restore the effectiveness of immune cells fighting cancer, slowing tumor growth, and increasing lifespan in mouse models of melanoma, bladder cancer, leukemia, and colon cancer. One of the most prevalent genetic abnormalities observed in multiple…

The American Association for Cancer Research (AACR) released its annual Cancer Progress Report on Wednesday that highlighted advances in cancer treatments and survival while also advocating for continued funding by the US government to sustain progress. “The advances in cancer research, particularly in the last two decades, have been breathtaking,”…

Just four-and-a-half minutes of vigorous activity during daily tasks could reduce the risk of some cancers by up to 32%, according to a large-scale observational study that used data from wearables. Vigorous Intermittent Lifestyle Physical Activity, or ‘VILPA’, was associated with a substantially lower cancer risk in those who engaged…

Magnetic resonance-guided daily adaptive stereotactic body radiotherapy (MRg-A-SBRT) significantly lowers the risk for acute genitourinary and gastrointestinal toxicity in patients with prostate cancer relative to standard computed tomography-guided non-adaptive prostate SBRT (CT-SBRT), shows a pooled analysis of previously published data. First author of the review, Jonathan Leeman, from the Dana‐Farber…

GDF-15’s role in resistance to cancer immunotherapy was reinforced in a Nature Communications study published today. The researchers demonstrated that GDF-15 blocks LFA-1-dependent T cell recruitment into the tumor microenvironment, a prerequisite for responses to anti-PD-1/-L1 treatment and other immunotherapeutic strategies. This, the authors say, is the first paper to…

A new study in Cancer Cell reveals evolutionary clues in the tumor microenvironment during gastric cancer progression. Researchers from the University of Texas MD Anderson Cancer Center learned that the presence of certain types of cell groupings were linked with clinical outcomes. The study provides a high-resolution gastric cancer tumor…

Obesity has been previously linked to an increased risk of cancer, but most studies have not differentiated the risks between male and female patients. A prospective study of more than 400,000 UK Biobank participants, carried out by researchers at Uppsala University, has now found that both overall fat accumulation and…

A blood test based on RNA and AI delivered 87% sensitivity and 95% specificity of detection across eight cancer types, according to results Exai Bio presented in a poster session at ASCO last weekend. This is an important new aspect to the highly competitive multi-cancer early detection (MCED) market. Most…

Patient-derived tumor organoids—3D tissue cultures derived from tumor tissue samples—could be used to predict the most suitable treatment for patients with biliary tract cancer, suggests research presented at Digestive Disease Week 2023 in Chicago. Biliary tract cancers are relatively uncommon (around 8000 people in the United States are diagnosed with…