Protein folding is a fundamental function in the mundane operations of a cell’s daily life. Yet, when this task goes wrong, it becomes readily apparent how vital of a role 3D structure plays for the vast majority of protein molecules. In the past, scientists concluded that the aberrantly assembled proteins…

A faster and easier approach to genetically reprogram cells, compared to current viral and electroporation methods is being explored by scientists based at the Fred Hutchinson Cancer Research Center. According to these scientists, nanoparticles can be used to deliver transient gene changes to targeted cells, making therapies for a variety…

GNS Healthcare, a provider of analytic solutions to pharmaceutical and health plan customers, said it has raised an additional $6 million in equity toward further development of its Reverse Engineering & Forward Simulation (REFS) causal machine learning and simulation platform and solutions. The equity was raised from Amgen Ventures, Amgen’s…

Researchers at the Indiana University (IU) School of Medicine claim they have developed blood tests for detecting suicide risk both in the general population and for specific types groups at risk for suicide. In addition, the team showed how two apps—one based on a suicide-risk checklist, and the other on…

Vanderbilt University Medical Center (VUMC) and the University of Arizona College of Pharmacy researchers have generated a first-of-its-kind comprehensive catalog of diseases associated with variations in human leukocyte antigen (HLA) genes that regulate the body's immune system. The report, published in the journal Science Translational Medicine, confirmed a broad selection…

The promise of regnerative medicine to grow human tissue outside the body using pluripotent stem cells and to use that tissue to treat diseases such as diabetes has shown siginificant potential. But recent work by Harvard researchers determined that human pluripotent stem cells are prone to develop mutations in the…

The Human Vaccines Project and Vanderbilt University Medical Center will use the next-generation sequencing tools and expertise of Illumina to decipher the genes and proteins that make up the human immune system. The Human Immunome Program, coordinated by the Vanderbilt Institute for Clinical and Translational Research, aims to determine key…

Regeneron Genetics Center (RGC), a subsidiary of Regeneron Pharmaceuticals, announced it will collaborate with GlaxoSmithKline (GSK) and UK Biobank to generate genetic sequence data from the health database's 500,000 volunteers participants, with the aim of providing new genetic evidence to researchers in developing new therapeutics across a broad range of…

A team of investigators lead by researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, along with their African collaborators from the University of Nigeria and University of Ghana Medical School have assembled data from a genome-wide association study (GWAS) that was searching…

Investigators from the Lund University Diabetes Centre in Sweden have been able to map the entire methylome in the insulin-producing pancreatic islets, measuring individual gene function and expression. The findings from this study were published recently in Diabetes through an article entitled “Whole-genome Bisulfite Sequencing of Human Pancreatic Islets Reveals…

Researchers at The University of Texas Health Science Center at Houston (UTHealth) have just developed a framework to understand how whole genome sequence (WGS) data can be analyzed to identify genetic variations that raise or lower risk of disease. The findings from this new study were published recently in the American…

Researchers at the Institute for Research in Biomedicine (IRB Barcelona) have recently identified 10 new possible combination therapies to treat breast cancer based using an in silico method to analyze cell signaling networks and 64 known drug pairings currently used to treat the disease, according to an advance publication of…

Nonprofit genomic analysis organization the Translational Genomics Research Institute (TGen) and California-based City of Hope have announced a collaboration to apply genomic research toward clinical practice through a partnership in which TGen will become a City of Hope subsidiary. The partnership aims to combine TGen’s expertise in genomic analysis and…

The International Phenome Centre Network (IPCN), a worldwide consortium of research centers focused on disease prevention, detection and treatment by better understanding the dynamic interactions of our genes and our environment in the development and progression disease, launched November 29 with the goal of tackling pressing global health challenges including autism,…

At the American Society of Human Genetics (ASHG) 2016 Annual Meeting in Vancouver, B.C., researchers from Harvard Medical School, the Broad Institute, and Brigham and Women's Hospital (BWH) presented data of a large-scale, genome-wide analysis of more than 110,000 samples. The researchers reported that the data, which had been collected by the…