Huntington’s disease (HD) is a progressive brain disorder caused by mutations in the HTT gene, which encodes the protein huntingtin. The HTT mutation is a CAG trinucleotide repeat that, when repeated more than 36 times, can lead to the disorder that is characterized by uncontrolled movements and loss of cognition.…

Researchers from an NIH-funded consortium are preparing to recruit nearly 2,600 participants whose data will be incorporated into maps of the molecular changes to the human body wrought by exercise—maps that may lead someday to greater use of personalized exercise regimens or exercise-mimetic drugs for people unable to exercise. The…

While the clinical world has just begun to realize the promise of genomics to inform more precise care for individual patients, scientists also are pushing ahead with the development of clinical tools using other ’omics. The studies of proteins and metabolites—proteomics and metabolomics, respectively—offer considerable promise. In most cases, though,…

Scientists at the Wellcome Sanger Institute, Open Targets, Biogen, GSK, and their collaborators say they have found that T cells responded differently to immune signals the more “training” they had been exposed to, rather than being a simple switch from naïve to experienced. This could help guide research into finding…

German oncology company, Indivumed, is launching an international collaborative—the Oncology Alliance for Individualized Medicine—to advance the personalized treatment of cancer through multi-omics analysis and machine learning. The Alliance, dubbed Onco AI-Med, will make use of Indivumed’s multi-omics database, IndivuType, to accelerate new insights into the personalized treatment of cancer. The…

A team of investigators at the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn have just published findings from a new metastudy that found artificial intelligence can detect one of the most common forms of blood cancer—acute myeloid leukemia (AML)—with high reliability. The research teams’ approach was…

Indivumed said today it will add proteomic and phosphoproteomic data to its IndivuType multi-omics cancer database through a collaboration with Biognosys whose value was not disclosed. The collaboration is intended to enhance the IndivuType database by adding proteome-level data from thousands of samples using Biognosys’ proteomics technology, with the goal…

As 2020 approaches, it is fair to say that significant—and perhaps surprising—advances will be made in the precision medicine and omics arenas, as there were in 2019. While we don’t know for sure what lies ahead for 2020, six industry leaders have shared with Clinical OMICs and now you, our…

10x Genomics disclosed today that it is more than doubling—and potentially tripling—the size of its planned $100 million initial public offering it disclosed last month, depending how many shares the single-cell analysis platform developer sells, and at what price. In an S-1/A amended registration statement, 10x Genomics set a price…

10x Genomics has disclosed plans to raise $100 million through an initial public offering, according to a registration statement filed with the U.S. Securities and Exchange Commission—five months after the company was among six up-and-comers recognized by Clinical OMICs as Five-Year Super Successes in Genomics and Precision Medicine. Headquartered in…

Q-State Biosciences and 2bPrecise are partnering to build robust clinical-genomic datasets to help healthcare providers better leverage precision medicine for patients with genetic conditions. The partnership is backed by 2bPrecise’s parent company, Allscripts Healthcare Solutions, which is a healthcare information technology leader. The deal combines 2bPrecise’s cloud-based, EHR (electronic health…

The mechanisms that underlie the progression of MS are not well understood. Now, an international, multi-institutional team of researchers has studied pathological events at a higher resolution than has been done in the past, describing the gene expression, at the single cell level, of the major cell types found in…

Preterm birth is one of the leading causes of infant mortality. Approximately 10% of babies born in the U.S. in 2018 were born before 37 weeks gestation, according to the U.S. Centers for Disease Control and Prevention (CDC). The CDC also reports that the risk of preterm birth in 2016…

The possibility of metabolomics playing a role in cancer diagnostics and treat- ment seems, to many metabolomicists, a question of when rather than if. After all, metabolomics is a powerful platform to measure the endpoint of human physiology—a direct readout of physiological changes—and is easily sampled in blood. Despite its…

Researchers from the lab of Bart Deplancke, PhD, at the École Polytechnique Federale de Lausanne (EPFL) Institute of Bioengineering say they have developed a new method called Bulk RNA Barcoding and sequencing (BRB-seq) which is 25 times less expensive than conventional commercial RNA sequencing technology. Among its many advantages, BRB-seq is quick and…